![]() The reduction in dead space ventilation correlated with baseline physiological dead space fraction (r2=0.36 p<0.05), but not with respiratory rate or anatomical dead space volume.During sleep, NHF decreases minute ventilation due to an overall reduction in dead space ventilation in proportion to the extent of baseline physiological dead space fraction.Īn elevated physiological dead space, calculated from measurements of arterial CO2 and mixed expired CO2, has proven to be a useful clinical marker of prognosis both for patients with acute respiratory distress syndrome and for patients with severe heart failure. min−1 pThere was a significant decrease in dead space ventilation (from 2.5☐.4 to 1.6☐.4 L NHF reduced minute ventilation (from 5.6☐.4 to 4.8☐.4 L We measured CO2 production and calculated dead space ventilation.Controls and COPD patients responded similarly to NHF. ![]() min−1) intermittently for periods of 5–10 min.During stable non-rapid eye movement stage 2 sleep, subjects received NHF (20 L We hypothesised NHF reduces ventilation in proportion to physiological but not anatomical dead space.11 subjects (five controls and six chronic obstructive pulmonary disease (COPD) patients) underwent polysomnography with transcutaneous carbon dioxide (CO2) monitoring under a metabolic hood. Nasal high flow (NHF) reduces minute ventilation and ventilatory loads during sleep but the mechanisms are not clear.
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